Interactions between an inflammatory response to infection and protein trafficking pathways favor correction of defective protein trafficking in Cystic Fibrosis
نویسندگان
چکیده
منابع مشابه
Interactions between an inflammatory response to infection and protein trafficking pathways favor correction of defective protein trafficking in Cystic Fibrosis
One unresolved issue in Cystic Fibrosis research is how functional loss of CFTR, a protein involved in chloride transport, results in chronic lung inflammation. Large scale experiments investigating protein or gene expression changes due to altered trafficking of the most common disease causing CFTR mutation (ΔF508) have produced long lists of changes with no apparent connection to inflammation...
متن کاملDifferences in growth promotion, drug response and intracellular protein trafficking of FLT3 mutants
Objective(s): Mutant forms FMS-like tyrosine kinase-3 (FLT3), are reported in 25% of childhood acute lymphoid leukemia (ALL) and 30% of acute myeloid leukemia (AML) patients. In this study, drug response, growth promoting, and protein trafficking of FLT3 wild-type was compared with two active mutants (Internal Tandem Duplication (ITD)) and D835Y. Materials and Methods:FLT3 was expressed on fact...
متن کاملdifferences in growth promotion, drug response and intracellular protein trafficking of flt3 mutants
objective(s): mutant forms fms-like tyrosine kinase-3 (flt3), are reported in 25% of childhood acute lymphoid leukemia (all) and 30% of acute myeloid leukemia (aml) patients. in this study, drug response, growth promoting, and protein trafficking of flt3 wild-type was compared with two active mutants (internal tandem duplication (itd)) and d835y. materials and methods:flt3 was expressed on fact...
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Morbidity and mortality in cystic fibrosis (CF) are due not only to abnormal epithelial cell function, but also to an abnormal immune response. We have shown previously that macrophages lacking CF transmembrane conductance regulator (CFTR), the gene mutated in CF, contribute significantly to the hyperinflammatory response observed in CF. In this study, we show that lack of functional CFTR in mu...
متن کاملAnalysis of Lipolytic Protein Trafficking and Interactions
This work examined the colocalization, trafficking, and interactions of key proteins involved in lipolysis during brief cAMPdependent protein kinase A (PKA) activation. Double label immunofluorescence analysis of 3T3-L1 adipocytes indicated that PKA activation increases the translocation of hormonesensitive lipase (HSL) to perilipin A (Plin)-containing droplets and increases the colocalization ...
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ژورنال
عنوان ژورنال: Bioinformation
سال: 2010
ISSN: 0973-8894,0973-2063
DOI: 10.6026/97320630005228